4-[(E)-2-(3,4,5-Trimethoxyphenyl)vinyl]phenol

4-[(E)-2-(3,4,5-Trimethoxyphenyl)vinyl]phenol - Names and Identifiers

Name	(E)-4-[2-(3,4,5-trimethoxyphenyl)ethenyl]-Phenol
Synonyms	(E)-4-(3,4,5-Trimethoxystyryl)phenol 4-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 4-[(E)-2-(3,4,5-Trimethoxyphenyl)vinyl]phenol 4-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol (E)-4-[2-(3,4,5-trimethoxyphenyl)ethenyl]-Phenol phenol, 4-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]- Phenol, 4-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
CAS	116519-00-7
EINECS	1312995-182-4
InChI	InChI=1/C17H18O4/c1-19-15-10-13(11-16(20-2)17(15)21-3)5-4-12-6-8-14(18)9-7-12/h4-11,18H,1-3H3/b5-4+

4-[(E)-2-(3,4,5-Trimethoxyphenyl)vinyl]phenol - Physico-chemical Properties

Molecular Formula	C17H18O4
Molar Mass	286.32
Density	1.177±0.06 g/cm3(Predicted)
Melting Point	191 °C(Solv: acetic acid, 80% (64-19-7))
Boling Point	440.2±40.0 °C(Predicted)
Flash Point	220°C
Vapor Presure	2.33E-08mmHg at 25°C
pKa	9.92±0.26(Predicted)
Storage Condition	2-8°C
Refractive Index	1.621

4-[(E)-2-(3,4,5-Trimethoxyphenyl)vinyl]phenol - Introduction

(E)-4 '-Hydroxy-3, 4,5-trimethoxystilbene is an organic compound often abbreviated as HMME. It has a molecular formula of C17H16O3 and a molecular weight of 268.31g/mol.

Nature:
HMME is a colorless to yellow solid, soluble in organic solvents such as ether and methylene chloride, and practically insoluble in water. It has a strong aromatic smell.

Use:
HMME is an important synthetic intermediate, which has a wide range of applications in the fields of medicine, pesticide and dye. One of the most important is in medicine as a targeted drug for photodynamic therapy (PDT). It can absorb visible light and the occurrence of internal photosensitive reaction, produce reactive oxygen species, thereby destroying cell membranes and tissues, cancer cells and other diseased tissues have a killing effect.

Method:
The most commonly used method of preparing HMME is through a substitution reaction with toluene. Specifically, toluene first reacts with sodium hydroxide to obtain p-methylphenol, then reacts with cuprous bromide to generate cuprous species, and finally HMME is synthesized by bromination with aryl.

Safety Information:
HMME is a toxic substance that may cause irritation and injury on contact with the skin and by inhalation. Use and handle should wear gloves, goggles and masks, maintain a well-ventilated laboratory environment. At the same time, contact with strong oxidants and strong acids should be avoided to avoid dangerous reactions. If accidentally inhaled or contact, should promptly seek medical attention. In the use and storage should strictly abide by the relevant safety procedures.

Last Update：2024-04-09 21:11:58